Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [4] Pepcid (Famotidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Get Pepcid heartburn relief products in tablets, chewables, and maximum strength formats. Famotidine is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Famotidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. PEPCID® is the original famotidine brand and, for 35 years, has been effective and safe acid reducer when used as directed. PEPCID® is clinically proven to provide heartburn relief and is backed by 50+ clinical studies. Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. Overview: Famotidine is used to treat heartburn, ulcers, and other conditions caused by too much stomach acid. It is available by prescription and over-the-counter (OTC). Famotidine is an H2. Pepcid is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Pepcid is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Famotidine (Pepcid and Zantac) treats conditions that cause too much stomach acid, like heartburn, stomach ulcers and reflux disease. PEPCID® is a histamine-2 blocker (H2 blocker) with the active ingredient famotidine that helps relieve heartburn by reducing the amount of acid in the stomach.